WEEK 5 NFL PICKS FOR BET REGAL

JACKSONVILLE AT BUFFALO (-6), in London

The Bills (3-1) have outscored their opponents 133-33 in three straight wins, including a lopsided statement victory over the Dolphins. They’ve got a tough matchup overseas facing the Jaguars (2-2) in Jacksonville’s second straight game in London.

BILLS, 29-24

PHILADELPHIA (-4) AT LOS ANGELES RAMS

The undefeated Eagles (4-0) just keep winning in different ways, overcoming sluggish starts and defensive breakdowns. The Rams (2-2) are playing better than expected, but Matthew Stafford is banged up just as Cooper Kupp is getting set to return.

BEST BET: EAGLES, 27-16

NEW YORK JETS AT DENVER (-2.5)

The Jets (1-3) are coming off a close loss to the Super Bowl champs in Zach Wilson’s best game, and are playing for Nathaniel Hackett, who was ripped in comments by Broncos coach Sean Payton before the season. Russell Wilson rode the Broncos (1-3) to a comeback victory over the Bears last week but New York’s defense is far tougher than Chicago’s.

UPSET SPECIAL: JETS, 20-17

HOUSTON AT ATLANTA (-2)

C.J. Stroud has been impressive leading the Texans (2-2) to consecutive wins. Desmond Ridder has struggled for the Falcons (2-2) and Atlanta’s offense was dismal the past two games. Giving the ball to Bijan Robinson 25-30 times could be the winning formula vs. Houston.

Falcons, 23-20

CAROLINA AT DETROIT (-9.5)

The Lions (3-1) are rolling and determined to live up to the preseason hype. Bryce Young and the Panthers (0-4) are suffering through major growing pains.

LIONS, 30-16

TENNESSEE (-2.5) AT INDIANAPOLIS

The Titans (2-2) finally got their offense going by giving the ball to Derrick Henry. The Colts (2-2) are waiting to get a jolt from Jonathan Taylor while rookie QB Anthony Richardson continues to show promise.

Colts, 20-16

NEW YORK GIANTS AT MIAMI (-12.5)

Tua Tagovailoa and the Dolphins (3-1) found out the road to the AFC East title still goes through Buffalo. They should get back on track against the pitiful Giants (1-3).

Dolphins, 30-17

BALTIMORE (-4.5) AT PITTSBURGH

Lamar Jackson is healthy, the Ravens (3-1) already beat two divisional rivals on the road and are favored to do it again. The Steelers (2-2) may not have Kenny Pickett and it’s unknown which team shows up. They were blown out by Houston last week after consecutive wins.

Steelers, 22-20

NEW ORLEANS AT NEW ENGLAND (-1)

The Patriots (1-3) have to rebound after Bill Belichick suffered the worst loss of his coaching career at Dallas. The Saints (2-2) were dominated at home by the Buccaneers and haven’t gotten their offense going with new QB Derek Carr.

PATRIOTS, 20-17

CINCINNATI (-3) AT ARIZONA

Joe Burrow’s calf injury has impacted his performance and the Bengals (1-3) are off to a terrible start. They should get better against the Cardinals (1-3).

BENGALS, 26-17

KANSAS CITY (-3.5) AT MINNESOTA

A potential shootout between Patrick Mahomes and Kirk Cousins but the Chiefs (3-1) have a better defense than the Vikings (1-3).

CHIEFS, 29-24

DALLAS AT SAN FRANCISCO (-3.5)

The Cowboys (3-1) seeking to avenge being eliminated in the playoffs two years in a row by the 49ers (4-0). Could be a preview of the NFC title game. The 49ers are the NFL’s most complete team right now.

49ERS, 23-22

GREEN BAY AT LAS VEGAS (-2)

All-Pro receiver Davante Adams faces his former team. Jimmy Garoppolo should be back from a concussion to throw passes to Adams as the Raiders (1-3) try to snap a three-game losing streak. The Packers (2-2) have a banged-up offensive line that’s making things difficult for Jordan Love and the run game.

RAIDERS, 24-20

Last week: Straight up: 11-5. Against spread: 7-8-1

Overall: Straight up: 39-25. Against spread: 32-29-3.

Best Bet: Straight up: 4-0. Against spread: 2-1-1.

Upset Special: Straight up: 2-2. Against spread: 2-2.

Thursday: Straight up: 3-1. Against spread: 4-0.

Monday: Straight up: 4-2. Against spread: 4-1-1.

(Canadian Press)